Jamgon Loter Wangpo, also known as Jamyang Loter Wangpo, was born as the son of Pasang Norbu and Yonten Kyi near Samdup Tse, in Tsang Nyangmed Tibet. 

At a young age, he joined Ngor Ewam Monastery where he studied ritual practices from Acharya Sonam Phuntsok, along with literature, astrology, and other subjects from Pandita Jigme Palden. He intensively studied the profound teachings on the three vows from his root guru Thartse Khenchen Jampa Kunga Tenzin. He received full ordination from the abbot of Thartse, Jampa Kunga Tenpai Gyaltsen, and his own paternal uncle Ponlop Namkha Gyaltsen.

He was enthroned as the Vajra master of Ngor Ewam monastery at the age of twenty-three. Jamgon Loter Wangpo was an excellent and accomplished scholar whose main teachers were Jamyang Khyentse Wangpo, Jampa Kunga Tenpai Gyaltsen, and Jamgon Kongtrul Lodro Taye. Like his great teacher Jamyang Khyentse Wangpo, Jamgon Loter Wangpo is associated with the non-sectarian movement.

Jamyang Khyentse Wangpo was his main inspiration for and the patron of Jamyang Loter Wangpo’s Collection of Tantras. He also gave oral transmissions of Kangyur and other profound teachings. He became a renowned and accomplished scholar. His main disciples were Dzogchen Shenga Rinpoche, Khyentse Chokyi Lodro, Dezhung Ajam, and Thartse Jamyang Kunga Tenpa’i Gyaltsen.